Turn-Key
Mixing and Homogenizing Systems

For Emulsions, Suspensions and Powders.

Mixing and Homogenizing Systems

symex Quality Standards

Technical Standards

  • Pressure vessels PED (AD 2000), ASME, CRN, JIS, GOST, SELO
  • Electrics / Control VDE, UL, CUL, CSA,
  • Hygiene GMP, cGMP, GEP, GAMP, USDA, 3A, FDA / 21 CFR Part 11
  • Controls Siemens, Rockwell (Allen Bradley), Wonderware etc.
  • Explosion protection ATEX, NEC 500 / NEC 505
  • CE, OSHA and all other national and international standards for safety

For the highest GMP Requirements

  • GEP-compliant engineering
  •  cGMP/EG-GMP/GAMP compliant design, construction and manufacturing concept
  • Detailed qualification concept (DQ, IQ, OQ, PQ, RA)
  • Material and weld seam documentation
  • Innovative fully automated CIP/SIP concept
  • Operating concept for process reliability and reproducibility
  • FDA-compliant user management
  • FDA 21 CFR Part 11 compliant electronic process data recording
  • Audit trail for maximum traceability
  • FDA compliant scale-up system
  • Customer and process-specific training and education programs
  • Maintenance and service programs for maximum system availability

Mixing system for every industry

Cosmetics/ Personal Care

  • Creams, Serums
  • Shower Gels
  • Bodylotion
  • Deodorants
  • Foundation
  • Make-up
  • Lipstick
  • Lip Gloss
  • Mascara, Eyeliner
  • Concealer
  • Shampoo
  • Conditioner
  • Hair Spray
  • Coloring
  • sunscreen
  • Fragrances
  • Shaving Cream
  • Peelings

Powders:

  • Rouge
  • Bronzer
  • Eye Shadow
  • Body Powder

Pharma/ Healthcare

    • Cough syrup
    • Eye/ Ear Drops
    • Nasal Spray
    • Suppository
    • Ointments, Creams
    • Toothpaste
    • Adhesive Cream
    • Tablet Coatings
    • Infusion Solutions
    • Gel
    • Capsules

    Powders:

    • Antibiotic Powder
    • Sparkling Powder

Chemistry

  • Lubricants
  • Colors
  • Grease
  • Fertilizer
  • Varnishes, Glazes
  • Adhesives
  • Shoe polish
  • Car Polish

Powders:

  • Powdered Glues/ Adhesives
  • Detergents
  • Fillers

Food products

  • Ketchup, Mayonnaise
  • Sauces, Dressings
  • Dairy Products

Powders:

  • Baby Food
  • Whey Protein Powder
  • Nutritional Supplement

Mixing and homogenizing system for emulsions and suspensions

  • Stainless steel pressure/vacuum vessel with double jacket
  • Coaxial agitator with central and scraper agitator
  • Co-Twister rotor-rotor homogenizer
  • Raw material dosing system
  • External and internal circulation line with flow measurement
  • Temperature control system
  • Vacuum system
  • Transfer system as a link between pre-phase container and mixing system
  • Fully automatic CIP/SIP cleaning system
  • Fully automatic recipe management and system control
  • Closed machine stand (optional)
  • Premix vessel and operating platform (optional)
  • Independent control of flow and shear (rotor-rotor principle)
  • Control of the mixing profile in the container all speeds and viscosities
  • Precise temperature control with control accuracy of +/- 0,5°C
  • Fully automatic CIP/SIP cleaning, sterilization and drying
  • Repeatable product circulation first-in-first-out principle
  • Homogenizer intake housing
  • Parameterizable intake valves for liquids, powders, granules, pellets
  • Hot-/Cold emulsification process
  • Controlled transfer rates and mixed concentrations
  • Fully automatic recipe management and process control
  • Repeatable product quality (100% homogeneous active ingredient distribution, at any speed and viscosity)
  • Reduction of process times (by up to 75%)
  • Product stability through 100% product homogeneity
  • Reduction of cleaning times and media consumption (up to 85%)
  • Validated cleaning results (complete cleaning between 20 and 45 minutes)
  • Batch size flexibility from 10 – 100% batch size
  • Cosmetics: Creams, lotions, sunscreen, make-up, foundation, mascara, eyeliner, lipstick, toothpaste.
  • Pharmaceuticals: Tablet coatings, cough syrups and syrups, ear and eye drops, suppository masses, ointments, gels, active ingredient solutions and dispersions.
  • Chemicals: Lubricants and dyes, adhesives, coatings, varnishes, fertilizers, car polishes.
  • Food: Ketchup, mayonnaise, sauces and dressings, baby food, food supplements.

Standard Installations of Mixing and Homogenizing Systems

Click on the points in the graph for detailed information.

1
2
3
4
5
6
7
8
1

Mixing System

2

Premix Unit

3

Temperature Control Units

4

Vacuum Pump

5

Transfer Pump

6

Control Cabinet/ symex Control

7

Operating Platform

8

CIP/SIP Cleaning Station

Reference Mixing and Homogenizing System

CMF 3.000 Ex + PM 2.100 Ex

CML 5.000 + PML 3.500 + PM 600 + AUX 50 + AUX 50

CML 2.000 + PM 1.450

CML 3.500 + PML 2.500

CML 60 Ex

CML 2.000 Ex

CML 2.000 Ex

CML 2.000 + PML 1.450

CML 1.000 Ex + PM 600 Ex

CML 300 + PM 220

CML 2.000 Ex CC49 + PML 1.450 Ex CC49

CMF 10.000 + 3x P 10.000 + KZE

CML 50 Ex + PM 35 Ex

CML 200 + PM 160

Reference Mixing and Homogenizing System

CMF 3.000 Ex + PM 2.100 Ex

CML 5.000 + PML 3.500 + PM 600 + AUX 50 + AUX 50

CML 2.000 + PM 1.450

CML 3.500 + PML 2.500

CML 60 Ex

CML 2.000 Ex

CML 2.000 Ex

CML 2.000 + PML 1.450

CML 1.000 Ex + PM 600 Ex

CML 300 + PM 220

CML 2.000 Ex CC49 + PML 1.450 Ex CC49

CMF 10.000 + 3x P 10.000 + KZE

CML 50 Ex + PM 35 Ex

CML 200 + PM 160

Mobile Mixer

  • Stainless steel pressure/vacuum vessel with double jacket
  • syBot pump-agitator
  • External pumping line
  • Quick couplings for media supply
  • Transfer connection to main mixer, pre-phase tank or discharge
  • Fully automatic CIP/SIP cleaning system
  • Fully automatic recipe management and system control
  • Sight glass and vessel lighting
  • Extremely fast melting of solids (flakes, granules, chips, etc.)
  • Very high pumping performance even at highest viscosity
  • First-in-first-out homogenization via external pumping line
  • Precise temperature control with control accuracy of +/- 0,5°C
  • Lid opening for the addition of raw materials
  • Vacuum function for venting
  • Mobile container on wheels
  • Cleaning CIP/ SIP Advanced, sterilization and drying (quick coupling)
  • Fully automatic recipe management and process control (quick coupling)
  • Small (manual) premixes become unnecessary
  • Production batch 100% validated
  • Quick couplings to the main mixing station, including automatic size and type recognition regardless of container size
  • Universally operable and interchangeable across the entire symex production fleet
  • Batch size flexibility from 10 – 100% batch size
  • Extreme product/phase type flexibility
  • 100% validated, documented and traceable production
  • Fully integrated into CIP / SIP processes
  • Cosmetics: Creams, lotions, sunscreen, make-up, foundation, mascara, eyeliner, lipstick, toothpaste.
  • Pharmaceuticals: Tablet coatings, cough syrups and syrups, ear and eye drops, suppository masses, ointments, gels, active ingredient solutions and dispersions.
  • Chemicals: Lubricants and dyes, adhesives, coatings, varnishes, fertilizers, car polishes.
  • Food: Ketchup, mayonnaise, sauces and dressings, baby food, food supplements.

Reference Systems Mobile Mixer

AUX 50 + AUX 30

CMF 9.500 + PML 6.000 + PM 1.450 + AUX 50 + AUX 30

Reference Systems Mobile Mixer

AUX 50 + AUX 30

CMF 9.500 + PML 6.000 + PM 1.450 + AUX 50 + AUX 30

Laboratory Mixer

Laboratory Mixer CML 10 + PM 8

  • Two stainless steel pressure/vacuum vessels with double jacket
  • Coaxial agitator with central and scraper agitator
  • Rotor-stator homogenizer
  • External pumping line
  • Suction system for powders and liquids
  • Phase container with usable volume of 8 liters with agitator
  • Temperature control system
  • Vacuum system
  • Fully automatic CIP/SIP cleaning system
  • System control via manual valves and touch display including user management and process data recording
  • Mobile version with usable volume of 2 to 10 liters
  • Plug & Play connection
  • Two process phases
  • Plug & Play connection
  • Lid lift
  • Homogenizer and agitator infinitely adjustable
  • Extremely fast melting of solids (flakes, granules, chips, etc.)
  • Very high pumping performance even at highest viscosity
  • First-in-first-out homogenization via external pumping line
  • Precise temperature control with control accuracy of +/- 0,5°C
  • Vacuum function for venting
  • 100% Scalable
  • Ideal for test and sample series in the context of product and process development
  • Turnkey system
  • All process-relevant process components on a small scale
  • Exact measurement data that can be transferred to real production mixing plants
  • Manually operated
  • Extreme product/phase type flexibility
  • 100% validated, documented and traceable tests
  • Cosmetics: Creams, lotions, sunscreen, make-up, foundation, mascara, eyeliner, lipstick, toothpaste.
  • Pharmaceuticals: Tablet coatings, cough syrups and syrups, ear and eye drops, suppository masses, ointments, gels, active ingredient solutions and dispersions.
  • Chemicals: Lubricants and dyes, adhesives, coatings, varnishes, fertilizers, car polishes.
  • Food: Ketchup, mayonnaise, sauces and dressings, baby food, food supplements.

Laboratory Mixer CML 4

  • Stainless steel pressure/vacuum vessel with double jacket
  • Anchor agitator with two baffles and temperature sensor
  • Rotor-stator homogenizer with internal pumping line
  • External circulation line with flow meter
  • Suction system for powders and liquids
  • Dosing funnel for raw materials/cleaners
  • Temperature control system
  • Vacuum system
  • CIP/SIP cleaning system
  • System control via manual valves
  • Touch display including user management and process data recording
  • Mobile laboratory table with usable volume of 1 to 4 liters
  • Plug & Play connection
  • Lid lift
  • Homogenizer and agitator infinitely adjustable
  • Extremely fast melting of solids (flakes, granules, chips, etc.)
  • Very high pumping performance even at highest viscosity
  • First-in-first-out homogenization via external pumping line
  • Precise temperature control with control accuracy of +/- 0,5°C
  • Vacuum function for venting
  • 100% Scalable
  • Ideal for test and sample series in product development
  • Turnkey system
  • All process-relevant process components on a small scale
  • Exact measurement data that can be transferred to real production mixing plants
  • Manually operated
  • Extreme product/phase type flexibility
  • 100% validated, documented and traceable tests
  • Cosmetics: Creams, lotions, sunscreen, make-up, foundation, mascara, eyeliner, lipstick, toothpaste.
  • Pharmaceuticals: Tablet coatings, cough syrups and syrups, ear and eye drops, suppository masses, ointments, gels, active ingredient solutions and dispersions.
  • Chemicals: Lubricants and dyes, adhesives, coatings, varnishes, fertilizers, car polishes.
  • Food: Ketchup, mayonnaise, sauces and dressings, baby food, food supplements.

Reference Systems Laboratory Mixer

CML4

CML 10 + PM 8

Reference Systems Laboratory Mixer

CML4

CML 10 + PM 8

Powder Mixer

  • Stainless steel pressure/vacuum vessel with double jacket
  • Coaxial agitator with central and scraper agitator
  • Co-Twister homogenizer for crushing and homogenizing
  • Fully automatic recipe management and system control
  • Temperature control system
  • Vacuum system
  • Transfer system as a link between pre-phase container and mixing system
  • Fully automatic CIP/SIP cleaning system
  • Fully automatic recipe management and system control
  • Crushing and homogenizing in one process step
  • High energy input due to counter-rotation of the mixing unit (60 – 80 m/s relative speed)
  • Precise application of binding agents through the finest nozzles
  • Drying function via vacuum and heating (e.g. removal of solvents)
  • Precise temperature control of +/- 0,5°C. of +/- 0,5°C
  • Excellent statistical particle size distribution
  • No cyclone formation due to the counter-rotation of the tools
  • Vortex destruction by the premixing blade
  • Dry dispersion
  • Fully automatic CIP/SIP cleaning, sterilization and drying
  • Fully automatic recipe management and process control
  • Repeatable product quality (viscosity, particle size distribution and stability – without color correction)
  • Very short mixing times (less than 4 minutes)
  • Gentle and precise crushing and processing of e.g. color pigments
  • Maximum flexibility from intensive deagglomeration to gentle homogenization
  • No extra transfer of the product into the next process container (grinding and mixing in one process step)
  • Product stability through 100% product homogeneity
  • Validated cleaning results Fully automatic cleaning and sterilization concept, including water and detergent addition.
  • Batch size flexibility from 10 – 100% batch size
  • Cosmetics: Blush, eye shadow, bronzer, highlighter, dry shampoo, coloring powder, hair styling powder, body and face powder.
  • Pharmaceuticals: Powders for inhalation, powders for infusions and vaccines, antibiotics in powder form.
  • Food: Dietary supplements, infant milk powder

Reference Systems Powder Mixer

CPM 200 Ex

Reference Systems Powder Mixer

CPM 200 Ex

Continuous Mixer

  • Stainless steel pressure/vacuum vessel with double jacket
  • Co-Twister In-Line Homogenizer
  • Mixed modules can be selected statically or dynamically
  • Modular dosing line concept
  • Temperature control system
  • Vacuum system
  • Fully automatic recipe management and system control
  • Fully automatic CIP/SIP cleaning system
  • Start-up time only 15 seconds until the target mass flow is reached without start-up losses
  • Mass production, up to 16 tons/hour
  • pH in-line measurement and adjustment via special dosing line
  • Air-free production – No foaming during the production of WAS products.
  • Dosing line concept for up to 30 different dosing lines
  • Fully automatic CIP/SIP cleaning, sterilization and drying
  • Repeatable product quality
  • Hot-/Cold emulsification process
  • Controlled transfer rates and mixed concentrations
  • Fully automatic recipe management and process control
  • Repeatable product quality
  • Reduction of processing times
  • Product stability through 100% product homogeneity
  • Batch size flexibility from 10 – 100% batch size
  • Up to 30 different dosing lines
  •  1/3 cost savings compared to batch systems with the same production output
  • Fully automated production without personnel
  • Tailor-made recipe management with variable throughput adjustment
  • Individual design for all products and throughput sizes
  • Cosmetics: Body, skin and hair care products.
  • Pharmaceuticals: Ointments, gels, solutions, suspensions.
  • Chemicals: Cleaning agents, varnishes and paints.
  • Food: Sauces and dressings, baked goods, beverages.

Reference Systems Continuous Mixer

Reference Systems Continuous Mixer

Storage Vessels

  • Stainless steel pressure/vacuum vessel with double jacket
  • Agitator (optional)
  • Discharge device
  • Vacuum system
  • Fully automatic CIP/SIP cleaning system
  • Precise temperature control with control accuracy of +/- 0,5°C
  • Fully automatic CIP/SIP cleaning, sterilization and drying
  • Repeatable product circulation first-in-first-out principle
  • Made from high quality materials such as stainless steel to ensure corrosion resistance and durability
  • Available in different sizes from 10 to 20.000 liters.
  • Quality / Hygiene Execution: GMP, cGMP, GEP, GAMP, USDA, 3A, FDA / 21 CFR Part 11.
  • Explosion protection: ATEX, NEC 500 / NEC 505.
  • CE, OSHA safety standards.
  • Seamless integration which increases the efficiency of the production process.
  • Designed for easy and loss-free emptying and dispensing.
  • Enables flexible adaptation and expansion of storage capacities.

Reference Systems Storage Container

Reference Systems Storage Container

Service Team

    Email: sales@symex.de

     Phone: 0471 98401-0

Andree Schaumkell-Scholz

Andree Schaumkell-Scholz
Sales & Process Engineering

Stefan Schultz
Sales & Process Engineering

Marko Stuthmann

Marko Stuthmann
Sales & Process Engineering

Wolfgang Richert
Sales & Process Engineering

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